304 Collagent tripeptide may modulate inflammation in atopic dermatitis

Dermatitis IgE and Acute Inflammation in Atopic Decreased IL-15 May Contribute to Elevated

Common Allergens in Patients with Atopic Dermatitis

Abstract Background and objective: Being exposed to different allergens, followed by the production of specific IgE, has an important role in causing atopic dermatitis, recognizing the allergens and applying immunotherapy for treatment. We aimed to determine the frequency of common allergens in the patients suffering from atopic dermatitis. Material and Methods: In this descriptive- anal...

The underlying mechanisms of skin inflammation in atopic dermatitis

The underlying mechanisms of skin inflammation in atopic dermatitis (AD) are not completely understood but inflammatory cell activation and dysregulated cytokine production appear to play a critical role in pathogenesis of AD. Inducible nitric oxide synthase (iNOS) is expressed by dermal endothelial cells and perivascular inflammatory cells in the atopic skin lesion, suggesting the involement o...

The Missing Link between Itch and Inflammation in Atopic Dermatitis

Atopic dermatitis is a common skin disease with high morbidity and is associated with severe itch and chronic skin inflammation. In this issue of Cell, Wilson et al. demonstrate that epithelial cells communicate directly with cutaneous sensory neurons via a cytokine to induce itch.

TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis

Atopic dermatitis (AD) and psoriasis are driven by alternate type 2 and type 17 immune responses, but some proteins might be critical to both diseases. Here we show that a deficiency of the TNF superfamily molecule TWEAK (TNFSF12) in mice results in defective maintenance of AD-specific T helper type 2 (Th2) and psoriasis-specific Th17 cells in the skin, and impaired expression of disease-charac...